595 results
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
Thresholds for Transfusion of Platelets in Adults
Major surgery or invasive procedure, no active bleeding - 
≤
Transfusion of Platelets ... procedure, no active bleeding ... neurosurgery, no active bleeding ... Surgery with active bleeding ... #Management #Platelets
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
common inherited bleeding ... bruising • Skin bleeding ... • Prolonged bleeding ... Laboratory • Normal platelet
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis and Bleeding ... Thrombosis Increased Platelet-Vesset ... #Thrombosis #Bleeding
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Sequestration Disordered Platelet ... Coagulation #Bleeding
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... - History of bleeding ... epistaxis, gingival bleeding ... Thrombocytopenia #Platelet
Mount Sinai COVID-19 Anticoagulation Algorithm

Inclusion: All admitted patients with COVID-19
Exclusion: High risk of bleeding as judged
: High risk of bleeding ... High-risk for bleeding ... , consider: - Platelet ... Current or recent bleeding
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... areas of skin bleeding ... predictive of serious bleeding ... lowest levels Platelet ... ability to bind platelets