27 results
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... diphosphate; PF-3, platelet ... Pathophysiology #Coagulation ... #Cascade #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... cascade is shown ... multicomponent complexes on platelets ... #Coagulation #Cascade ... #platelet #thrombin
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
Thromboelastogram Interpretation ... representing thrombin-platelet ... - Treatment: Platelets ... Thromboelastogram #TEG #Interpretation ... Thromboelastography #diagnosis #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Differential Diagnosis Algorithm ... vs Acquired • Platelet ... Qualitative • Coagulation ... Differential #Diagnosis #Algorithm
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... vascular disorders, coagulation ... Thrombocytopenia • Platelet ... defects • Coagulation ... NON-PALPABLE PURPURA: Platelet
THROMBOELASTOGRAPHY (TEG)
General Principle
• A small cuvette is rotated to simulate sluggish venous flow and stimulate clot
problems with coagulation ... cascade and platelet ... CriticalCare #Hematology #Interpretation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... Treat primary cause ... #diagnosis #causes
Thromboelastography (trademarked as TEG)
 • Graphical representation of the fibrin polymerization process
 • Point-of-care anti-coagulation monitoring
Point-of-care anti-coagulation ... routine transfusion algorithms ... amplitude • If ↓ → platelet ... deficiency → give platelets ... Thromboelastogram #TEG #interpretation
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... Differential #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders