36 results
diagnosis hematology management algorithm leukemia syndrome syndromes chronic classification disorders lymphocytic myelodysplastic neurology neutropenia otolaryngology otology pulmonary rheumatology thrombocytopenia workup
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... • Marrow Aplasia ... Inflammation • Cancer ... #Differential #
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... Myelodysplastic #Syndrome #MDS ... #hematology #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... : • Recurrent infections ... Treatment: • Consider ... stem cell transplant ... Can progress to MDS
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... anemia Treatment ... #Anemia #oncology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... malignancies • Infection ... Myelofibrosis Stem cell ... • Toxins • Aplastic ... Anemia • Myelodysplasia
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... ITP • SLE • CLL ... Vasculitis • Infection
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... - infiltrates (anemia ... lymphoid organs When Cancer ... Leukemia #Hematology #Oncology
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... Pylori • Hookworm infection ... Iron #Deficiency #differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
marrow failure: Aplastic ... infiltration (e.g. cancer ... , infection), Marrow ... defects (e.g. sickle cell ... #differential #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... weeks without infection ... • Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment
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