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diagnosis management differential algorithm hemeonc leukemia workup chronic dermatology hemophagocytic hlh lymphocytic lymphohistiocytosis mds mgus monoclonal myelodysplastic neutropenia rheumatology syndrome
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Hemolysis - Polychromatic ... Inflammation • Cancer ... #Hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Reticulocytosis/polychromasia ... Hemolysis #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Myelofibrosis Stem cell ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... Diagnosis #Algorithm #Causes
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... stem cell transplant ... #management #treatment ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... Allogeneic stem cell ... #hematology #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... ITP • SLE • CLL ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... anemia Treatment ... #Anemia #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... • Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
marrow failure: Aplastic ... anemia, Marrow ... infiltration (e.g. cancer ... defects (e.g. sickle cell ... Production #Index #hematology
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