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Polycythemia (Erythrocytosis) - Pathophysiology

#Polycythemia #Erythrocytosis #Pathophysiology #hematology #algorithm #differential #diagnosis
Polycythemia (Erythrocytosis ... Pathophysiology #Polycythemia ... #Erythrocytosis
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm
Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... (Erythrocytosis ... Increased PMNs • Polycythemia ... Pulmonary Disease #Polycythemia ... #Erythrocytosis
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... Diagnosis Secondary Thrombocytosis ... a.k.a Reactive Thrombocytosis ... Autonomous Thrombocytosis ... thrombocythemia (ET) • Polycythemia
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - ... Thrombocythemia • Polycythemia ... BrighamChiefs #Thrombocytosis
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm

Elevated Hemoglobin:
 • Males: Hb > 16.5 g/dL/HCT ≥ 49%
 •
Erythrocytosis - ... Polycythemia Differential ... dL/HCT ≥ 48% Polycythemia ... MatthewHoMD #Erythrocytosis ... #Polycythemia #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... • Essential thrombocytosis ... • Polycythemia ... deficiency anemia #Thrombocytosis
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
bcr-able (-) - Polycythemia ... PV), Essential Thrombocytosis ... (MF), Reactive Thrombocytosis
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hydroxyurea - Thrombocytosis ... Plateletpheresis - Polycythemia
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
disorders (eg. polycythemia ... vera, essential thrombocytosis
Newborn Infant - Routine Examination

Birthweight, gestational age and birthweight percentile are noted.
General observation Of the baby's
Newborn Infant - ... checked to identify polycythaemia ... #Newborn #Infant