11 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... Proteinuria often ... damage from systemic ... diabetes)) #Glomerular ... #Classification
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic ... hematuria and/or proteinuria ... the patient have glomerular ... #Nephritic #Nephrotic ... Syndrome #Comparison #Algorithm
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... central nervous system ... clusters because nephritic ... #Algorithm #differential ... #proteinuria #nephrotic
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
with evidence of glomerular ... disease (hematuria, proteinuria ... immune deposits in glomeruli ... nephropathy, lupus nephritis ... Glomerulonephritis #RPGN #Classification
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... • Hereditary nephritis ... and >3.5g/day (nephrotic ... range) proteinuria ... Differential #Diagnosis #Algorithm
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
SLE Hallmark = proteinuria ... severity (ISN/RPS classification ... therapy Goal: proteinuria ... by 12 months Classification ... Focal LN (<50% of glomeruli
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Renal domain: Proteinuria ... II or V lupus nephritis ... Ill or IV lupus nephritis
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
vasoconstriction-hemodynamically mediated - Systemic ... INTRINSIC: - Glomerular ... red blood cells/proteinuria ... Management: Avoiding nephrotoxic
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
Lupus Nephritis ... associated with systemic ... develops new: • Proteinuria ... with evidence of proteinuria ... #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... proteinuria, hematuria ... proteinuria, dependent ... Neuropsychiatric systemic