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liver transaminitis algorithm function interpretation management rheumatology tests vasculitis anemia aplastic arterial causes chemistry classification dili elevated embolism gastroenterology hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... ) - Differential ... 1000): • DILI (Drug-induced ... liver injury) ... Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential ... #diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... Burak @kwburak #LFTs ... #hepatology #LiverFunctionTests
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Diagnosis Algorithm ... disease US — Normal ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... Differential Diagnosis ... valproate, azoles), Drugs ... Diagnosis #hepatology ... Transaminitis #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
) - Normal Values ... hepatocellular injury ... impaired uptake (drugs ... Interpretation #diagnosis ... #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... • Intravenous Drug ... Pregnancy • Drugs ... Vasculitis • Injury ... pathophysiology #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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