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Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... on Smear • Chronic ... Decreased RBC ... Spherocytes on Smear ... Diagnosis #Algorithm #Causes
Plasmodium Falciparum Blood Smear. Key features suggesting Plasmodium falciparum: - extreme parasitemia - normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... parasitemia - normocytic RBCs ... multiples per RBC ... P. falciparum causes ... human malaria cases
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... Neutrophils - Low RBC ... Pernicious Anemia RBCs ... Diagnosis #Algorithm #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Peripheral blood smear ... Hypochromic & microcytic RBCs ... Diagnosis #Algorithm #causes
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Hematologic disease caused ... anorexia, ARDS ​• RBC ... phase: Peripheral smear ... coccobacillus within the RBCs
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
fetus/newborn the causes ... BloodSmear #Blood #Smear ... #Nucleated #RBCs
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
↑ LDH • Anti-RBC ... C3d • Blood smear ... 2) LOOK FOR a cause
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... ordering a peripheral smear ... the most likely cause ... recovery also causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Peripheral smear ... Treat primary cause ... hydration • RBC ... Coagulation #diagnosis #causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... ) - Abnormal RBCs ... Diagnosis #Algorithm #Causes
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