2631 results
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology
Risk factors:
 - Low CD4 count
 - Disseminated OI
 -
Reconstitution Inflammatory Syndrome ... of inflammatory response ... duration or OI treatment ... cellular immune responses ... #Inflammatory #Syndrome
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
symptoms, and less response ... anti-synthetase syndrome ... after 2 years of treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Stiff Person Syndrome ... an autoimmune response ... positive therapeutic response ... Treatment: • ... Diagnosis #Management #treatment
Horner's Syndrome on Physical Exam

A 75yoF was referred in for facial swelling and eyelid changes 1
Horner's Syndrome ... diagnosis of Horner's syndrome ... or induced by treatment ... the sympathetic response ... anterior_seg_rocks #Horners #Syndrome
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Pathophysiology: • Immune response ... Miller Fisher Syndrome ... Treatment: • Plasmapheresis ... diagnosis #management #treatment
Systemic Inflammatory Response Syndrome (SIRS)
•	Non-specific (infections vs non-infectious)
•	≥2 of the following:
o	Temp >38°C or <36°C
o	HR >90 bpm
o	RR
Systemic Inflammatory Response ... Syndrome (SIRS) ... dysregulated host response ... recognition & treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... blast cells → SIRS response ... Renal Failure Treatment ... Differentiation #Syndrome
Tongue Pathology 

Geographic tongue, fissured tongue, and hairy tongue are the most common tongue problems and
do not require treatment ... infection and responds ... Burning mouth syndrome ... tongue and has responded ... to treatment with
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... • Bicytopenia Treatment ... If no response HLH ... diagnosis #management #treatment
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... Pathergy (an inflamed response ... tests in Behcet syndrome ... adenopathy (PFAPA) syndrome ... Arthritis, AS Treatment