15 results
Table of Causes of Acute Liver Injury
#Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Liver Injury #Diagnosis ... #Hepatology #Acute ... #Liver #Injury ... #Causes #Differential ... Incidence #Table #Failure
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... ) - Differential ... Hepatopathy • Acute ... Drug-induced liver injury ... Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
- Differential ... evidence of liver failure ... Differential Diagnosis ... Diagnosis #hepatology ... Transaminitis #LFTs
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... #hepatology #LFTs ... transaminitis #differential ... #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Drug-Induced Liver Injury ... #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Supportive with treatment ... liver failure ... Hepatobiliary #hepatology ... #hepatitis #differential ... #diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Liver Failure ( ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Diagnosis Framework ... Insufficiency, Liver Failure ... Medications, Spinal Cord Injury ... #Diagnosis #criticalcare
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... Renal Failure ... Treatment: • Steroids ... #management #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
subclinical disease to acute ... liver failure ... pattern of liver injury ... regarding need for treatment ... #Management #Hepatology