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Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Decreased renal potassium ... Drugs Increased potassium ... Diabetic Nephropathy Renin ... Normal, Renin High ... hypoplasia Aldosterone high
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... mmol creatinine) High ... Low-normal EABV, High ... piperacillin • High ... hypokalemia #urine #potassium
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... urinary losses: • High ... Pressure: - ↑ Renin ... tumor - ↓ Renin ... #differential #potassium
Etiologies of Hypoaldosteronism Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone) - Diabetic Nephropathy - NSAIDs Non-Hyporeninemic Hypoaldosteronism (Normal
Hypoaldosteronism (Normal or High ... insufficiency - Critical ... Resistance (Normal or High ... Renin, Normal or ... High Aldosterone
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypertensive: • High ... aldosteronism • High ... Al, High R - Secondary ... renovascular HT, Renin-secreting ... #causes #low #potassium
Hyperaldosteronism - Etiologies of Mineralocorticoid Excess Primary Hyperaldosteronism (Normal or Low Renin, High Aldosterone) - Aldosterone-secreting
(Normal or Low Renin ... , High Aldosterone ... Hyperaldosteronism (High ... Renin, High Aldosterone ... (Normal or Low Renin
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Syndrome • HTN, High ... Renovascular HTN, Renin ... Algorithm #causes #potassium
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... ARBs Decreased Renin ... Pharmacology #Impaired #Potassium
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS) This is a very common pathway that clinicians should
review of the Renin-Angiotensin-Aldosterone ... with excreting potassium ... will increase potassium ... , which is why potassium ... #Pharmacology #Renin
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Hyperkalemia • Direct renin ... Aliskiren) • Renin ... #pharmacology #potassium
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