49 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... erythematosus (SLE ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... rheumatology #diagnosis #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Farr assay) and lupus ... with MCTD and Raynaud's ... Lupusreference #Antinuclear
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... rheumatology #diagnosis #differential
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... • Specific for SLE ... #Systemic #Lupus
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Photosensitivity 29% - Raynaud's ... involvement 3% SLE-Related ... Auto-Antibodies ... (aPL) 30-45% Differential ... Lupusreference #SLE
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
antineutrophil cytoplasmic antibodies ... antineutrophil cytoplasmic antibodies ... antineutrophil cytoplasmic antibodies ... ; SLE, systemic ... lupus erythematosus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... in drug-induced SLE ... Antineutrophil #antibodies
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Discoid Rash A Antinuclear ... #IMDAMNSHARP #sle ... #systemic #lupus
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

 -
Raynaud Phenomenon ... Differential Diagnosis ... sclerosis, RA, SLE ... #Diagnosis #Reynaud ... Phenomenon #Syndrome #Differential
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... Cytoplasmic #Patterns #differential