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diagnosis rheumatology ana differential antibody testing antibodies cytoplasmic erythematosus management nuclear systemic autoantibodies sjogrens sle summary syndrome table
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Nuclear Patterns ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Homogeneous: Systemic lupus ... , Drug-induced Lupus ... Kumfer @AnnKumfer #Antinuclear ... Antibodies #ANA #patterns
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... serial dilution, a pattern ... significant • Pattern ... : The ANA patterns ... Kumfer @AnnKumfer #Antinuclear
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... #Systemic #Lupus
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Farr assay) and lupus ... with MCTD and Raynaud's ... Lupusreference #Antinuclear
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear Patterns ... Homogeneous pattern ... SSc, PM/SSc OS, Raynaud ... ARUPLabs #ANA #Antinuclear
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic Patterns ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... #Cytoplasmic #Patterns
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Cryoglobulinemia (4%-12%), Raynaud ... Adenocarcinoma Treatment
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