30 results
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
Calcinosis • Raynaud ... diagnosis #signs #symptoms ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Erythematosus - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... Summary #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
thickening Signs and Symptoms ... • Vascular: Raynaud's ... Scleroderma #SSc #rheumatology ... diagnosis #signs #symptoms ... #testing #workup
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... with MCTD and Raynaud's ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
Rheumatologic Review of Systems (ROS): 
•	Fevers
•	Rashes/photosensitivity
•	Alopecia
•	Nail/nailfold abnormalities
•	Sicca symptoms
•	Conjunctivitis
•	Uveitis
•	Episcleritis
•	Scleritis
•	Raynaud's
•	Oral/genital ulcers
•	Polychondritis
•	Enthesitis
•	Serositis sx
•	Thomboses
•	Neuropathy
•	Pregnancy loss.

#Rheumatologic #rheumatology #ROS #ReviewOfSystems #diagnosis #history
Rheumatologic Review ... abnormalities • Sicca symptoms ... • Scleritis • Raynaud's ... #Rheumatologic # ... rheumatology #ROS
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... for specific symptoms ... 1,500 cells/µL Workup ... organ-specific signs or symptoms ... Differential #diagnosis #hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
defect (rare) Raynaud's ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Photosensitivity 29% - Raynaud's ... autoantibodies #signs #symptoms ... #differential #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology