21 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... for specific symptoms ... 1,500 cells/µL Workup ... organ-specific signs ... or symptoms (eg
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
and Symptoms: ... • Vascular: Raynaud's ... Scleroderma #SSc #rheumatology ... #symptoms #testing ... #workup
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
Calcinosis • Raynaud ... Scleroderma #diagnosis #signs ... #symptoms #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antibody #Testing ... differential #diagnosis #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... Testing Cytoplasmic ... CTD-ILD, IIM, Raynaud ... #Antibody #Testing ... differential #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
defect (rare) Raynaud's ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Photosensitivity 29% - Raynaud's ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antibody #Testing ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... /Symptoms Alopecia ... Lupus enteritis, Raynaud's ... #Symptoms #diagnosis ... #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
reticularis • Raynaud ... (Cold-induced symptoms ... Positive Coombs testing ... post infectious setting ... hemolytic #anemia #hematology