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Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... (SLE) - Typical ... Adenopathies, Lupus ... enteritis, Raynaud's ... Erythematosus #SLE
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... • Specific for SLE ... #Systemic #Lupus ... Erythematosus #SLE
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic lupus ... Farr assay) and lupus ... & drug-induced lupus ... , neonatal lupus ... with MCTD and Raynaud's
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Photosensitivity 29% - Raynaud's ... involvement 3% SLE-Related ... Lupusreference #SLE ... #Systemic #Lupus
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... (SLE) General: ... defect (rare) Raynaud's ... Thrombocytopenia #Lupus ... #SLE #systemic
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Reticularis, Vasculitis, Raynaud's ... Phenomenon #Lupus ... #SLE #Mucocutaneous
Raynaud's Syndrome - Washing off under hot water.
Raynaud phenomenon is an exaggerated vasoconstrictive response of the
Raynaud's Syndrome ... Raynaud phenomenon ... #Raynauds #Syndrome
Raynaud's Syndrome - Washing off under hot water wath.

Raynaud phenomenon is an exaggerated vasoconstrictive response of
Raynaud's Syndrome ... Raynaud phenomenon ... #Raynauds #Syndrome
Raynaud's Phenomenon on Physical Exam

#Raynauds #Syndrome #disease #phenomenon #clinical #video #physicalexam #fingers #hands #rheumatology
Raynaud's Phenomenon ... Physical Exam #Raynauds
Common Raynaud's Mimickers
 - Acrocyanosis
 - Chill blains (pernio)
 - Erythromelalgia
 - Frostbite
 - Achenbach's Syndrome

Dr.
Common Raynaud's ... AnnKumfer #Common #Raynauds