1971 results
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... Reticularis, Vasculitis, Raynaud's ... Phenomenon #Lupus #SLE ... pathophysiology #diagnosis
Common Raynaud's Mimickers
 - Acrocyanosis
 - Chill blains (pernio)
 - Erythromelalgia
 - Frostbite
 - Achenbach's Syndrome

Dr.
Common Raynaud's ... AnnKumfer #Common #Raynauds ... #Differential #Diagnosis ... #Causes #Mimics
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

 -
Raynaud Phenomenon ... Differential Diagnosis ... sclerosis, RA, SLE ... - Frostbite #Diagnosis ... #Reynaud #Phenomenon
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... RTA, TYPE I RTA Diagnosis ... Cryoglobulinemia (4%-12%), Raynaud
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Scl70 (in some cases ... SSc, PM/SSc OS, Raynaud ... Scl-70 (in some cases ... CTD-ILD, IIM, Raynaud ... #differential #diagnosis
Raynaud's phenomenon
The photos are compatible with the paleness phase of Raynaud's phenomenon , defined as reversible,
Raynaud's phenomenon ... paleness phase of Raynaud's ... Classically, three passes ... establish the diagnosis ... #Raynauds #phenomenon
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Anti-UI-ribonucleoprotein - 35% • Raynaud ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE ... #Summary #diagnosis
Drugs Causing Acute Pancreatitis

Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... #Pancreatitis #Causes ... #Differential #Diagnosis
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... with MCTD and Raynaud's ... higly specific for SLE ... erythematosus #diagnosis
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... Hyperkalemia is caused ... is rarely the sole ... dysfunction is common #Diagnosis ... #Differential #Causes