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Tranexamic Acid: Mechanism of Action - TXA is an anti-fibrinolytic - TXA is a synthetic analog
TXA ultimately reduces ... pathophysiology #hematology
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
fibrinolysis (reduces ... #Pharmacology #hematology
Flutycosine - Antibiotics Class Overview - Mechanism: 5-FC interferes with DNA and protein synthesis. Only
adverse effects = Hematologic ... be monitored to reduce
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
deficiency • Reduced ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
thrombin time • Reduced ... , V and II • Reduced ... treatment #management #hematology
Thromboelastography (trademarked as TEG) • Graphical representation of the fibrin polymerization process • Point-of-care anti-coagulation monitoring
been shown to reduce ... interpretation #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Reduced liver synthesis ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
cells is much reduced ... Anemia #oncology #hematology
Thiazide induced Hyponatremia - Pathophysiology • Reduced distal delivery • Inhibition of the NCC (dilution capcity)-
Thiazide induced ... Pathophysiology • Reduced ... mechanism • Reduced ... #Thiazide #induced
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Non malignant hematologic ... following EtOH induced ... states • Non-hematologic ... Algorithm #Causes #Hematology
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