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diagnosis hematology treatment algorithm myelodysplastic neurology pathophysiology causes dermatology mds nephrology signs symptoms tls workup abnormal acromegaly anemia anesthesia anesthesiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Anemia Clinical ... Constitutional Syndromes ... #Anemia #oncology ... hematology #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Diagnosis and Management ... dys- (abnormal) -plastic ... Myelodysplastic #Syndrome ... treatment #hematology #oncology
Purple Urine Bag Syndrome Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine Tryptophan → Indoxyl
Purple Urine Bag Syndrome ... Purple #Urine #Bag #Syndrome ... pathophysiology #clinical ... #photo #differential
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... myelodysplastic #syndrome ... #differential # ... #dermatology #oncology ... #clinical #skin
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
of Tumor Lysis Syndrome ... Calcium ≤ 7.0 mg/dL Clinical ... #TumorLysis #Syndrome ... TLS #diagnosis #management ... #oncology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS) - Differential ... capillary leak syndrome ... • Schnitzler syndrome ... Diagnosis #hematology #oncology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
considered for urgent referral ... presence of metabolic syndrome ... repeat testing or referral ... result in urgent referral ... Liver #Enzymes #Differential
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... - Workup and Management ... Treatment of Clinical ... #Tumor #Lysis #Syndrome ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Pure red cell aplasia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... initiation • Differential ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
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