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diagnosis causes algorithm clinical management nephrology cardiology pulmonary pocus table radiology neurology hematology ultrasound dermatology pathophysiology mnemonic ddxof workup pediatrics
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
intestinal calcium absorption ... and stimulates resorption ... Stimulate calcium reabsorption ... kidney, Stimulates resorption ... Pathophysiology #Differential
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - Differential ... Miscellaneous - Bone Resorption ... - Calcium Reabsorption ... Hypercalcemia #Differential
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
increased bone Ca2+ resorption ... increased GI Ca2+ absorption ... Hypercalcemia #Causes #differential
Serotonin Syndrome - THINK: FAST - FAST onset - FAST movements (agitation, akathisia, HYPERreflexia) - FAST
HYPERreflexia) - FAST resolution ... HYPOreflexia - SLOW resolution ... Toxicology #Comparison #Differentiate
Polyuria - Differential Diagnosis Solute Diuresis • Na intake/saline • Glucosuria: Hyperglycemia, SGLT-2 inhibitors • Urea: Exogenous
Polyuria - Differential ... breakdown, TPN, Resolution ... #Polyuria #Differential
When trying to differentiate between the two conditions think “FAST” with Serotonin Syndrome and “SLOW” with
When trying to differentiate ... HYPERreflexia) - FAST resolution ... HYPOreflexia - SLOW resolution
Causes of Hypocalcemia - Differential Diagnosis Decreased calcium absorption • Vitamin D deficiency -
Hypocalcemia - Differential ... excretion/reduced bone resorption ... resistance to bone resorption ... resistance to bone resorption ... #Hypocalcemia #Differential
Drug-Induced Thrombocytopenia The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
demonstrating resolution ... Thrombocytopenia #Differential
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 Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Hypercalcemia - Differential ... Cytokine-Mediated Bone Resorption ... Hypercalcemia #Differential
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... infiltrates) → high resolution ... Renal #Syndrome #differential
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