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differential systemic symptoms antibodies dermatology ana antinuclear management vasculitis autoimmune causes classification diseases erythematosus lupus myositis nephrology patterns sclerosis sle
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Systemic Sclerosis (Scleroderma ... 10% - 15% • Scleroderma ... renal crisis ... #diagnosis #signs ... #symptoms #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
, Polymyositis/Dermatomyositis ... systemic sclerosis/scleroderma ... systemic sclerosis/scleroderma ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... arterial HTN) • Renal ... : scleroderma renal ... #SSc #rheumatology ... #diagnosis #signs
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Seborrhea • Dermatomyositis ... Telangiectasia • Scleroderma ... Thickened skin • Scleroderma ... #differential #diagnosis ... #rheumatology
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
Systemic Findings in Dermatomyositis ... - Heliotrope sign ... or shawl sign ... #Dermatomyositis ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Systemic sclerosis (scleroderma ... Polymyositis and dermatomyositis ... polyangiitis without renal ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... hypertension • Scleroderma ... renal crisis • ... #differential #diagnosis ... #hematology #hemolysis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Polymyositis / Dermatomyositis ... Anti-Scl-70 - Scleroderma ... Associations #diseases #diagnosis ... #table #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... heliotrope rash, Shaw sign ... , holster sign, ... /full triad at diagnosis ... #rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
diseases - scleroderma ... syndrome - dermatomyositis ... Vasculitis #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
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