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diagnosis symptoms systemic differential lupus erythematosus management scleroderma vasculitis algorithm ana anca antibodies antibody antineutrophil antinuclear arthritis autoantibodies causes chronic
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Systemic Sclerosis ... • Scleroderma renal ... #Systemic #Sclerosis ... Scleroderma #diagnosis #signs ... #symptoms #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... arterial HTN) • Renal ... : scleroderma renal ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
severe disease & renal ... /systemic sclerosis ... • Specific for SLE ... Erythematosus #SLE ... Summary #diagnosis #rheumatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Metabolic • Renal ... Tuberculosis • Epstein-Barr ... Arthritis • SLE ... Depression • Multiple Sclerosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
involvement 3% SLE-Related ... malignancies, Multiple sclerosis ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... ) • Systemic sclerosis ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Abdominal pain (20%) Renal ... Thrombocytopenia #Lupus #SLE ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... or 0.5 g/day → renal ... VI - Advanced sclerosing ... treatment #management #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... , particularly scleritis ... purpura: strong sign ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Rheumatoid Arthritis - Signs ... Episcleritis, Scleritis ... Pericarditis • Renal ... Arthritis #RA #Signs ... Symptoms #diagnosis #rheumatology
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