25 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Medications #Pharmacology ... #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... anticoagulants (DOACs ... filtration rate; DOAC ... Anticoagulation #Management #Hematology ... #Oncology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Systemic Lupus Erythematosus ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... Puncture, EEG Treatment ... CNS #neurology #rheumatology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology ... #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... life-threatening • Treatment ... lupus #Systemic #Erythematosus ... Management #Summary #rheumatology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... by case) • Surgery ... #management #pharmacology ... #rheumatology