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diagnosis differential hematology symptoms algorithm causes erythematosus lupus management pathophysiology ra rheumatoid sle syndrome systemic temporal arteritis disease giantcell oncology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... yrs old; F>M Signs ... - Normocytic Anemia ... palpation - Vasculitic ... #Symptoms #Vasculitis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... ) Blood (75%): Anemia ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... HUS • DIC • Vasculitis ... Heart Valve) #Thrombocytopenia ... Algorithm #Causes #Hematology
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Rheumatoid Arthritis ... Disease, Rheumatoid Vasculitis ... #Rheumatoid #Arthritis ... RA #diagnosis #rheumatology ... #signs #symptoms
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... Diagnosis #Algorithm #workup ... #hematology #testing
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... - Hemolytic anemia ... Differential #Diagnosis #hematology ... #rheumatology #
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
recurrent fevers, vasculitis ... Abnormalities: macrocytic anemia ... , thrombocytopenia ... • giant cell arteritis ... Autoinflammatory #Somatic #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... changes), high MCV anemia ... Diagnosis #Causes #Workup ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... hemolysis, deficiency anemia ... Inflammatory Conditions: Rheumatologic ... , Vasculitides,
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... autoantibodies #signs ... #differential #rheumatology
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