32 results
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Symptoms of anemia or thrombocytopenia ... with anemia or thrombocytopenia ... uw_IMresidency #CLL #Chronic ... #oncology #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
• Rheumatoid Arthritis ... Age > 50 • Chronic ... Lymphocytic Leukemia ... (CBC with Lymphocytes ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... involvement CML (Chronic ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology
Approach to Gout
Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals
Treatment:
 • Weight loss, diet, d/c culprit
Diagnosis: r/o septic arthritis ... birefringent crystals Treatment ... Colchicine: Acute and chronic ... treatmentChronic ... #ULT #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Polycythemia Vera • Chronic ... : • Acute or Chronic ... effect following treatment ... following EtOH induced thrombocytopenia ... Algorithm #Causes #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Rich, Lymphocyte ... Responsive to Treatment ... growth, response to treatment ... Classification #pathophysiology ... #Hematology #Diagnosis
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
maculopapular rash, arthritis ... low ferritin, arthritis ... and chronic synovitis ... (40%) Treatment ... Disease #AOSD #rheumatology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Inflammatory arthritis ... Noninflammatory arthritis ... : • Acute or chronic ... Joint #Pain #MSK #rheumatology ... #approach #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... • Infections: Chronic