21 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... tissue disease ... #Antinuclear #Antibodies ... #rheumatology #diagnosis ... #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis ... #differential
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders - Differential ... Diagnosis Algorithm ... Erythematosus ( ... SLE), should have ... Joint #Disorders #msk
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies ... Diagnosis and Lupus ... Lupusreference #SLE ... #Erythematosus
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 40% Target: SS-A/Ro ... is clinically suspected ... #erythematosus ... #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... in drug-induced SLE ... Anti-Ro/SSA ... #diagnosis #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Clinical Domains ... least 2 joints • Neurologic ... Highly specific antibodies ... Classification #Criteria #SLE ... #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... SLE) Clinical ... Cerebrovascular Disease ... #Erythematosus ... #SLE #CNS #neurology
Demyelinating Diseases - Differential Diagnosis
 • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE
 •
Demyelinating Diseases ... - Differential ... : MS, ADEM, NMO, ... Polyarteritis nodosa, SLE ... #neurology