13 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
and Clinical Findings ... RA) or systemic lupus ... / Symptoms: - ... #Diagnosis #Signs ... #Symptoms
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 40% Target: SS-A/Ro ... -15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... • Sjögren syndrome ... Anti-Ro/SSA ... Antineutrophil #antibodies #diagnosis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... likely it will be clinically ... Syndrome (SS), ... #rheumatology #diagnosis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... disorders (Systemic lupus ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... ab • RF • Antinuclear ... salivary ducts Clinical ... phenomenon (16%) MSK
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... dermatomyositis, Sjogren ... Clinical Features ... : • Symptoms limited
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
renal failure Clinical ... are not caused ... skin (16-32%): lupus ... anterior/posterior MSK ... #Management #Signs
Posterior Ankle Impingement (Os Trigonum) Syndrome - MSK Radiology
Imaging Findings:
 • Os trigonum which has marrow
- MSK Radiology ... Case description ... flexion but no symptoms ... #clinical #Radiology ... #diagnosis #msk