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erythematosus lupus management ana antinuclear sle anca antibodies antibody antineutrophil antiphospholipid apls autoantibodies cerebritis classification cns cryoglobulinemia cryoglobulins differential diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
lupus erythematosus ... • Sjögren syndrome ... Anti-Ro/SSA ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... CNS #neurology #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... 40% Target: SS-A/Ro ... -15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Differential Diagnosis ... Clinical Features ... #Diagnosis #Rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Arthritis • Systemic ... Lupus Erythematosus ... Sicca) Syndrome ... Inflammatory #JointPain #MSK ... #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... : • Clinical triad ... lupus erythematosus ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Antibodies: Anti-Ro ... Antibodies: • Anti-Ro ... salivary ducts Clinical ... phenomenon (16%) MSK ... #Rheumatology #
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
the lymphatic system ... renal failure Clinical ... skin (16-32%): lupus ... anterior/posterior MSK ... 5-10%, nervous system
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... - 1 or more clinical ... maternal chromosomal causes ... excluded Testing: • Lupus ... #diagnosis #hematology
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