SJS antinuclear syndrome hematology anemia antibodies systemic rheumatology disease table anca

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ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... cases • Sjögren syndrome ... #rheumatology #

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

SLE), Sjogren's Syndrome ... (SS), Polymyositis ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... SLE), Sjogren's Syndrome ... (SS), Polymyositis ... #Antibodies #ANA ... #patterns #rheumatology

Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... Autoantibodies #Rheumatology ... #associations #table

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

c-ANCA - Vasculitis ... granulomatosis p-ANCA ... #diagnosis #table ... #rheumatology # ... antibodies

Sensitivity of the ANA in Autoimmune & Nonrheumatic Disease

#Diagnosis #Rheumatology #ANA #AntiNuclear #Antibodies #Sensitivity

Sensitivity of the ANA ... & Nonrheumatic Disease ... #Diagnosis #Rheumatology ... #ANA #AntiNuclear ... #Antibodies #Sensitivity

I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M Malar Rash
D

Discoid Rash A Antinuclear ... Pleuritis) H Hematologic ... Arthritis R Renal Disease ... IMDAMNSHARP #sle #systemic ... erythematosus #rheumatology

Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

- Summary Antinuclear ... (ANA) - 95% - Initial ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA

Classification of Vasculitis
Vasculitis of large vessels
- Arteritis temporalis (giant-cell arteritis)
- Takayasu

central nervous system ... small vessels - ANCA-associated ... Churg-Strauss syndrome ... - systemic ... Vessels #Diagnosis #Rheumatology

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