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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... #rheumatology # ... differential #diagnosis ... #causes
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Diagnosis Mnemonic ... D Discoid Rash ... sle #systemic #lupus ... erythematosus #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... many differential diagnoses ... 6) An annular rash ... #diagnosis #sle ... erythematosus #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... Sjogren's Syndrome (SS ... ANA #patterns #rheumatology ... #diagnosis #differential
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Discontinuation of causal ... Manifestations: Malar rash ... comparison #table #rheumatology ... #diagnosis #management
Causes of Pharyngitis - Differential Diagnosis
Infectious:
 • Bacterial: Group A Strep, Group B and C Strep,
Causes of Pharyngitis ... - Differential Diagnosis ... Viruses Autoimmune: Lupus ... stomatitis Drugs: SJS ... #Causes
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Scl70 (in some cases ... pattern: - SjS ... Scl-70 (in some cases ... #differential #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Diagnosis Manifestations ... 69% - Malar rash ... Differential Diagnosis ... Erythematosus #Diagnosis ... #differential #rheumatology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin Rash ... - Differential Diagnosis ... Bullous systemic lupus ... #Differential #Diagnosis ... #Algorithm #causes