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diagnosis differential management algorithm causes clinical treatment radiology neurology pathophysiology pulmonary cardiology infections hematology rheumatology table physicalexam nephrology signs dermatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... Sjogren's Syndrome (SS ... Kumfer @AnnKumfer #Antinuclear
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... ANA ≠ Autoimmune Disease ... Sjogren's Syndrome (SS ... • Rheumatic Diseases ... Kumfer @AnnKumfer #Antinuclear
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... 30-40% Target: SS-A ... with auto-immune diseases ... Lupusreference #Antinuclear
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... connective tissue disease ... 90% • Anti-GBM disease ... Jcortesizaguirr #ANA #Antinuclear ... #rheumatology #diseases
Systemic Autoimmune Disorders #RA #SS #Sjogren’s_Syndrome #Autoimmine_disorders
Disorders #RA #SS
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Arthritis R Renal Disease
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia, Chronic disease ... deficiency, Liver Disease ... Uremia, Liver disease ... RBC: Hemoglobin SS ... SD disease, S-beta
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... with more severe disease ... Used to monitor disease ... with more severe disease ... Treatment: • Mild disease
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell disease ... (diverse genotypes ... ): SS, SC, SE, Sβ ... Cold agglutinins disease ... , Hemoglobin H disease
Algorithm for the Diagnosis of Serotonin Syndrome - Serotonin syndrome is thought to be caused by
medication leading to SS ... association with SS ... extremities in SS
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