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diagnosis rheumatology differential treatment acr2021 causes hepatology dermatology guidelines arteritis granulomatosis nephrology polyangiitis table ana antibodies antinuclear autoantibodies classification erythematosus
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... vasculitis (Eosinophilic ... vasculitis (IgA-associated ... vasculitis, Behcet ... testing: anti-ANCA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... Vasculitis: + MPO-ANCA ... : • Behçet Syndrome ... • Cogan Syndrome
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... cases • Sjögren syndrome ... Vasculitis: • ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... glomerulonephritis 90%: - ANCA ... Associated Vasculitis ... Double Positive (ANCA ... Kumfer @AnnKumfer #Pulmonary
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (MPA) - ANCA ... Vasculitis Management ... Algorithm - ACR ... #Vasculitis #Management ... #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Graves' disease c-ANCA ... - Vasculitis, e.g ... granulomatosis p-ANCA ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
With associated pulmonary ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Active
Polyangiitis (EGPA) - ANCA ... Vasculitis Management ... Algorithm - ACR ... #Vasculitis #Management ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... • ANCA Associated ... Disease • Cogan syndrome ... #skin #dermatology ... #rheumatology #
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