26 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... life-threatening • Treatment ... #Systemic #Erythematosus ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Puncture, EEG Treatment ... RheumOnePagers) #Systemic ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • MCTD (SLE/systemic ... severe disease Treatment ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... • Immunologic Workup ... life-threatening • Treatment ... comparison #table #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... lupus Anti-dsDNA ... diseases only if Ag ... autoantibodies #Systemic ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lupus erythematosus ... lupus erythematosus ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Anterior Non-necrotizing Scleritis - Slit Lamp Ocular Examination

This 57 yo WM reported to clinic complaining of
no history of systemic ... patient was sent to rheumatology ... for further systemic ... workup and treatment ... #physicalexam #rheumatology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
female, asian • Systemic ... with response to treatment ... IgG4+ cells" Treatment ... management #phenotypes #workup ... #treatment #rheumatology
Holistic Management of Systemic Lupus
 • Lifestyle interventions: Smoking cessation, Photoprotection, Therapeutic adherence, Anxiety/depression/fatigue, Fibromyagia/pain management,
Management of Systemic ... Lupus • Lifestyle ... #Lupus #Erythematosus ... #management #treatment ... #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... myopathy • Anti MAG ... to cold IgG • Lupus ... Paraproteinemias #Hematology