12 results
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
Combination of Skin ... Suggestive of: Lupus ... Suggestive of: Lupus ... migrans: • Target sign ... Suggestive of systemic
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... of hip (rare), Arthritis ... erythematosus #signs
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... - Diagnosis Manifestations ... : - Arthritis ... 69% - Malar rash ... autoantibodies #signs
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... inflammation on skin ... Malar (butterfly) Rash ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... mucositis - Rash ... , arthritis LARGE ... lupus erythematosus ... purpura: strong sign
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... lesions (9.4%) • Maculopapular ... rash (6.7%) • ... • Giant cell arteritis ... #dermatology #rash
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Seizures • Strokes Skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... GCA (Giant Cell Arteritis ... , mucositis • Rash ... , arthritis Primary ... vesicles, pustules, maculopapular
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome Systemic ... , small-vessel vasculitis ... M > F Clinical Manifestations ... response to local skin ... diagnosis #management #signs