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differential dermatology rheumatology symptoms sle algorithm causes dermatomyositis erythematosus systemic vasculitis allergy anaphylaxis antimda5 antimda5dm antinxp2 antinxp2dm arthritis autoantibodies autoimmune
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... inflammation on skin ... Malar (butterfly) Rash ... pathophysiology #diagnosis ... #signs #symptoms
SKIN RASHES Skin rashes can occur from a variety of factors, including infections, heat, allergens, immune
SKIN RASHES ... Skin rashes ... rapid and accurate diagnosis ... fever and systemic signs ... petechiae; #purpura; #rash
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis Malar rash: • A
Combination of Skin ... - Differential Diagnosis ... Suggestive of: Lupus ... migrans: • Target sign ... #differential #diagnosis
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - ... Diagnostic Algorithm ... Ill-appearing, vital sign ... sulfa-drug - Skin ... #Maculopapular
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... 69% - Malar rash ... Differential Diagnosis ... Erythematosus #Diagnosis ... autoantibodies #signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... erythematosus #signs ... #symptoms #diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... lesions (9.4%) • Maculopapular ... rash (6.7%) • ... Differential Diagnosis ... #dermatology #rash
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
Manifestations of ... tongue and lips - Skin ... : urticarial rash ... cessation of play #Diagnosis ... #Allergy #Signs
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 ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous manifestations ... (blue-purple) rash ... • Erythematous rash ... anti-NXP2 Abs Lung Manifestations ... #dermatology #diagnosis
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin ... Rash - Differential ... Diagnosis Algorithm ... Auspitz sign, Koebner's ... soles • Discoid Lupus
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