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diagnosis rheumatology differential sle dermatology erythematosus management pathophysiology syndrome systemic vasculitis algorithm adult allergy antibiotics aosd arthropathies arthropathy autoantibodies autoimmune
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Sarcoidosis Non-caseating granulomas (Composed of T-helper & inflammatory cells) Clinical: • Disease fatal in 10% of
Clinical: • Disease ... neuropathies • Skin ... Subcutaneous nodules, lupus ... Sarcoidosis #Diagnosis #Symptoms ... #Signs #Pulmonary
Biphasic Illness of Leptospirosis Some patients do not progress to severe disease. Others, rapidly develop severe disease
develop severe disease ... brief interval symptom ... • Pretibial maculopapular ... rash • Others ... Diagnosis #Illness #Signs
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #symptoms #mimickers
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
arthritis - with the skin ... Polyarthritis • Systemic Lupus ... with Systemic Lupus ... should have other symptoms ... like “butterfly rash
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
plugging -> Discoid Rash ... inflammation on skin ... Malar (butterfly) Rash ... pathophysiology #diagnosis #signs ... #symptoms #complications
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... RA) or systemic lupus ... / Symptoms: - ... Xeroderma (Dry skin ... #Symptoms
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic Symptoms ... rash in association ... Symptoms: • The ... • Maculopapular ... Skin involvement
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... 3rd Decade Skin ... Photosensitive rash ... Seizures • Strokes Skin ... : • Symptoms limited
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
stages of this disease ... Skin rash and malaise ... The signs and symptoms ... late stages of disease ... caused by other diseases
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