21 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
rheumatoid arthritis (RA ... ) or systemic lupus ... erythematosus (SLE ... ) Signs / Symptoms ... Xeroderma (Dry skin
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... (15%) Skin (85% ... Butterfly rash, Vasculitis ... #SLE #systemic ... erythematosus #signs
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... gangrenosum • IBD • RA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... , Vasculitis (e.g ... enlargement - Sjögren's ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... Anticoagulant (LAC) • Sjogren ... ribonucleoprotein) • RA ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Associated with skin ... heart block • Sjogren ... #Lupus #Erythematosus ... diagnosis #rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... RA: rheumatoid arthritis ... SLE : systemic ... lupus. ... Table #Pulmonary #Rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
arthritis - (Reiter’s syndrome ... arthritis - with the skin ... Rheumatoid Arthritis (RA ... Lupus - with Systemic ... (SLE), should have
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... or RA - 5 to ... 20% Sjögren's syndrome ... lupus erythematosus ... classification #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... dermatomyositis, Sjogren ... Arthritis: • Joint ... #Systemic #Lupus