11 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... • Autoimmune diseases ... Drugs, Unknown cause ... Treatment: •
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... or autoimmune disease ... for refractory disease ... EricsMedicalLectures/ #HLH #Hemophagocytic ... #management #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
is rare in DIL, SCLE-DIL ... Discontinuation of causal ... life-threatening • Treatment ... Evolution: Chronic disease ... Lupusreference #druginduced
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... Alcohol-related liver disease ... hepatitis #DILI #DrugInduced ... Diagnosis #Algorithm #hepatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... Puncture, EEG Treatment ... CNS #neurology #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
advanced liver disease ... • Caused by splanchnic ... Pathophysiology: ... Treatment Overview ... Hepatorenal #Syndrome #Hepatology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... Discontinuation of causal ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
extrapulmonary disease ... or meningitic disease ... Inhalation of spores ... Aspergillosis Pathophysiology ... throat, skin, scalp
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... hyperinflammatory syndrome caused ... ▪ Autoimmune diseases ... Pathophysiology ... Diagnosis #Management #Hematology