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Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... weakness, less systemic ... heliotrope rash, Shaw ... triad of ILD, myositis ... #Autoimmune #Myositis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Gottron sign) • Shawl ... INCLUSION BODY MYOSITIS ... lung disease • Myositis ... • Conduction system
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Systemic Sclerosis ... involve DIP • Myositis ... @AnnKumfer #Systemic
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
periorbital heliotrope, shawl ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... Scleroderma) Multi-system ... Limited cutaneous systemic ... knees • Diffuse systemic ... acro-osteolysis, myositis
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
Cutaneous and Systemic ... V-neck sign or shawl ... Holster sign Systemic ... #Cutaneous #Systemic
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... Anti-PM-Sc1: Overlap myositis ... BCM_InternalMed #Systemic
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Normal CK - Myositis ... Osteoporosis #Systemic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... joints Nervous system ... Glomerulonephritis Myositis ... #Lupus #SLE #systemic
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
• Transverse myelitis ... positive NMO only): Myositis ... autoimmune disorders (Systemic
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