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differential anemia liver causes injury transaminitis hepatitis workup approach chemistry hepatocellular interpretation macrocytic microcytic monoclonal normocytic oncology pancytopenia paraproteinemias patterns
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... - Differential Diagnosis ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... #Diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Algorithm Low ... • Bleeding • Hemolysis ... #Classification ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... - Differential Diagnosis ... Algorithm Decreased ... #Algorithm #Causes ... #Hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
- Differential Diagnosis ... Algorithm • 12 ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Reticulocytes, MCV ... Non-lmmune #Anemia #Classification ... #Hematology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Infection (EBV/CMV ... 2-5x normal - Hemolysis ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (cell) volume (MCV ... acute blood loss, hemolysis ... #Diagnosis #Workup ... #Hematology #Microcytic
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... /B/C/D/E, EBV, CMV ... #Differential #Diagnosis ... #hepatology #algorithm ... Transaminitis #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Bilirubin: RBC (hemolysis ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
- Differential Diagnosis ... hyper-proliferative 2) Exclude hemolysis ... haptoglobin) 3) Use MCV ... #differential #diagnosis ... #hematology #algorithm
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