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Hypercalcemia Workup and Differential Diagnosis Framework 1) Determine whether PTH-dependent 2) Assess for other hormonal causes 3) Assess for
Hypercalcemia Workup ... and Differential Diagnosis ... other hormonal causes ... #endocrinology ... #calcium
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Pseudohyperparathyroidism, Renal ... )-alkali syndrome ... #diagnosis #calcium ... #high #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Differential Diagnosis ... Autosomal Dominant Calcium ... Other • Excess Calcium ... Immobilization • Adrenal ... #Algorithm #Endocrinology
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... Genetic disorders (e.g ... thyrotoxicosis, adrenal ... #Causes #Differential ... #Diagnosis #Endocrinology
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 Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... , adrenal, prostate ... • Milk-alkali syndrome ... #Causes #endocrinology
Hypokalemia Differential Diagnosis Algorithm Low intake • poor oral intake Renal loss • Medication • Hypomagnesemia •
Hypokalemia Differential ... Diagnosis Algorithm ... • Bartter's syndrome ... Transcellular shift ... #Algorithm #Causes
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Differential Diagnosis ... Tumors: Lung, SCC, renal ... Bony Mets - Calcium ... #Algorithm #causes ... #endocrinology
Hypophosphatemia - Differential Diagnosis Algorithm Transcellular Shift • Recovery From DKA • Refeeding Syndrome • Acute Respiratory
- Differential Diagnosis ... Transcellular Shift ... Alkalosis • Hypokalemia ... #Algorithm #endocrinology ... #causes
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
abnormalities - Hypercalcemia ... - Hypokalemia ... #Differential #Diagnosis ... Classification #Causes ... #Workup #hypomg
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... 1) Clinical clues ... #diagnosis #endocrinology ... #calcium #elevated ... #evaluation #workup
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