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management syndrome hemeonc hepatology alkaline apml causes cerebritis cns differential differentiation disorders emergencies erythematosus hemophagocytic hepatorenal hlh hrs hyophosphatasia leukostasis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
fractures of feet, thigh ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Hyperlipidemia - Hypercalcemia ... Hyophosphatasia #hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Induction Rx: high-dose ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... function test, ANA (e.g ... (CVID, WAS), (neurologic ... psychiatric changes), high ... not required in all
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... ATRA treatment Pathophysiology ... • Attempt if high ... #management #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... syndrome): - Hematologic ... plasmapheresis Hypercalcemia ... AML (~20 %) and APL ... #HemeOnc #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Lymphohistiocytosis (HLH) High ... • In all patients ... - Persistent high ... Pathophysiology ... #Management #Hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... liver insult (e.g ... Prognosis: • High ... evaluation essential in all ... #Nephrology #Diagnosis
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