89 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... pharmacology #potassium #medications
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... Thyrotoxicosis Medications ... Transcellular shifts ... MatthewHoMD #Hypokalemia
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
, Hypokalemia, Erectile ... higher risk of hyperkalemia ... failure - Co-medication ... Pgp-dependent drugs (e.g ... antihypertensive #medications
Emergency Management of Hyperkalemia in Adults
Assess Patient - Airway Breathing Circulation Disability Exposure (ABCDE) Approach
 •
Management of Hyperkalemia ... clinical scenario, ECG ... Gluconate IV Shift ... Consider cause of hyperkalaemia ... recurrence #Hyperkalemia
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... Refeeding Syndrome #Hypokalemia ... potassium #low #pathophysiology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Intracellular Shift ... Medications 2. ... causes #potassium #high
Osborn (J Wave)

Etiology 
• Hypothermia (below 320C / SOOF) 
• Normal variant 
• Hypercalcemia 
• Neurological
Normal variant • Hypercalcemia ... Neurological insult • Medications ... Differential #Cardiology #EKG ... #ECG #Hypothermia
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Curve Left Shift ... Temperature Right Shift ... ↑ 2,3-BPG • High ... Dissociation #Curve #pathophysiology
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... Hyperkalemia ... transcellular shifts ... The etiology of hyperkalemia ... renal function, medication
Constipation - Differential Diagnosis Algorithm
Diet/Lifestyle
 • Fibre
 • Calories
 • Fluid
 • Exercise
 • Psychosocial
Medications
 •
Psychosocial Medications ... Neurally Active Medications ... (e.g. ... Hypothyroidism • Hypokalemia ... • Hypercalcemia