11 results
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Action Along the Nephron ... AcuteKidneyInjury #AKI ... #Nephrology #Pathophysiology ... #Pharmacology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
action on the nephron ... Loop diuretic (e.g ... triamterene) #nephron ... #diuretics #pharmacology ... #nephrology #medications
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron ... Sites #Action #nephrology ... #pharmacology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
distal component of Nephron ... hyporenin hypoaldo, hyperkalemic ... absorption in distal nephron ... flow: Pre renal AKI ... KidneyDisease #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... vasoconstriction (e.g ... Abhilash Koratala @NephroP ... #AKI #causes ... Differential #Diagnosis #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
declines > ALT) • AKI ... • LDH ↑ • Hyperkalemia ... + myoglobin AKI ... Shift of extracellular ... causes #treatment #nephrology
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm

Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... through distal nephron ... • Low EABV (e.g ... renal failure • AKI ... IntercellularShift #Nephrology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... Transcellular Shift ... • Cell Lysis (e.g ... IntercellularShift #Nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... , RTA Type IV, AI ... heparinized tube) • ECG ... Terbutaline 7 µg/kg ... Treatment #potassium #nephrology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Is Dangerous in Hyperkalemia ... transcellular shift ... Saline Causes AKI ... NS #comparison #pharmacology