33 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... Hepatitis - Autoimmune ... hepatitis - Wilson disease ... #Differential #Hepatology ... #Diagnosis
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... agglutinin disease ... #antiglobulin #test ... #Hemolysis #hematology ... #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Diagnosis Hepatocellular ... Other: NAFLD, Autoimmune ... #algorithm #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Algorithm Symptoms ... of associated autoimmune ... disease (e.g. dryness ... disease, Persistent ... #Algorithm #hepatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... AIHA • Alloimmune ... AIHA • PCH ... #Algorithm #Causes ... #Hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... Autoimmune diseases ... Disorientation, vertigo Diagnostic ... #Urticaria #diagnosis ... #rheumatology #
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... Causes of Acute ... extrahepatic source - Tests ... #algorithm #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... : Warm AIHA, Cold ... Drug-associated, PCH ... Laboratory Tests ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... CLL (older) • Autoimmune ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... • Cholestatic disease ... Bile Ducts • PSC ... Others #LFTs #Hepatology ... #Algorithm #Causes