13 results
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose: Mechanism ... #pharmacology #mechanism ... #ammonia #hepatology ... #pathophysiology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Pharmacology #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Non-Infective Endocarditis - Pathophysiology
Non-infective Endocarditis Pathophysiology:
 • Valves usually undamaged - Etiology poorly understood but thought
Endocarditis - Pathophysiology ... Non-infective Endocarditis Pathophysiology ... different interacting mechanisms ... propagate → Vegetation forms ... NBTE #Marantic #pathophysiology
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
Tranexamic Acid: Mechanism ... Tranexamic #Acid #pathophysiology ... #hematology #TXA
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Mechanisms Driving ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
areas of stress) forms ... pulmonary fibrosis (mechanism ... RheumatoidArthritis #RA #pathophysiology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
Inherited forms ... the UB and CB forms ... The mechanism responsible ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : 2 hit mechanism ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
lesions and plaques form ... inflammation (complex mechanism ... Manifestations #pathophysiology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Synovial enlargement forms ... inflammation + other mechanisms ... RheumatoidArthritis #RA #pathophysiology