15 results
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose: Mechanism ... #pharmacology #mechanism ... #ammonia #hepatology ... #pathophysiology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Pharmacology #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
Tranexamic Acid: Mechanism ... Tranexamic #Acid #pathophysiology ... #hematology #TXA
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Mechanisms Driving ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
normalizes → Patient has ... normalize → Patient has ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Pathophysiology of Hepatorenal Syndrome - Dilation of splanchnic arteries initially compensated by increased CO eventually decompensates
Pathophysiology ... activation of mechanisms ... Hepatorenal #Syndrome #HRS
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : 2 hit mechanism ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... deformed shape, HbS ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Drug-Induced Edema
Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
occur via numerous mechanisms ... - Bradykinin (has ... #Pharmacology #Pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... DDX: • TMA’s (HUS ... - MAHA: TTP/HUS ... treatment #management #hematology