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diagnosis differential classification ana antinuclear associations autoantibodies pulmonary renal table algorithm antibody antineutrophil aortitis arthritis associated cryoglobulinemia cryoglobulins cutaneous dermatology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
- C-ANCA pattern ... antibody) - P-ANCA ... PR3 Anti-GBM disease ... #CANCA #PANCA # ... PR3 #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Vasculitis: • ... Microscopic polyangiitis ... Renal-limited vasculitis ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
hepatitis Anti-CCP, Rheumatoid ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Microscopic polyangiitis ... #antibodies
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... Diagnosis: Systemic rheumatic ... purpura: strong sign ... ) pattern: antibodies ... differential #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
others (RNP, aPL antibodies ... ribonucleoprotein) • RA: Rheumatoid ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... polyangiitis) - ANCA-negative ... erythematosus, Rheumatoid ... testing: anti-ANCA
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Purpura Anti-GBM antibodies ... Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... associated vasculitis ... (rare) • Rheumatic ... (IgG4-RD), Rheumatoid ... Differential #Diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Using fluorescence microscopy ... • Rheumatic Diseases ... #rheumatology #diagnosis
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of Vasculitis ... Vasculitis of ... small vessels - ANCA-associated ... granulomatosis - microscopic ... Vessels #Diagnosis #Rheumatology
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