19 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... context of other symptoms ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
(rare) • Rheumatic ... (IgG4-RD), Rheumatoid ... Arthritis (RA), Systemic ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... Neurologic system ... Vasculitis (e.g. ... Genitourinary system ... differential #diagnosis #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
hepatitis Anti-CCP, Rheumatoid ... c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... pain (20%) Renal disease ... #signs #symptoms ... #diagnosis #rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders ... secondary) • Rheumatoid ... autoimmune disease ... Erythematosus (SLE ... should have other symptoms
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... rheumaticum • Rheumatic ... Hypersensitivity vasculitis ... #dermatology #joint ... differential #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
vesicular eruption - Joints ... rheumatic diseases ... Symptoms (Sx) in ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Autoimmune diseases ... : - 10% SLE or ... - GPA, EGPA, microscopic ... classification #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
antibodies) • Systemic ... in drug-induced SLE ... ) • Systemic sclerosis ... : • Microscopic ... antibodies #diagnosis #rheumatology