38 results
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... Omeprazole, Sulfa drugs ... #diagnosis #pharmacology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... infection) - Drugs ... deficiencies (e.g ... Membrane defects (e.g
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
polyangiitis Drug ... • Antibiotics- eg ... /antipyretics- e.g ... Anticancer agents- eg ... Diagnosis #Differential
Torsades de Pointes 
•Precipitated by drugs that prolong the QT interval 
•Class IA antidysrhythmics (procainamide, quinidine)
Precipitated by drugs ... TorsadesDePointes #Diagnosis ... #Cardiology #ECG ... #EKG
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
calcineurin inhibitors (e.g ... Sympathomimetics (e.g ... decongestants) • Any drug ... anticholinergic effects (e.g ... #Medications #Drugs
Common sodium channel blockers which cause QRS widening.

Anticonvulsants: 
 - Carbamazepine 
Antidysrhythmics:  
 - Group
Antimalarial drugs ... Phenothiazines Drugs ... QRS #widening #ECG ... #EKG #Pharmacology ... #Differential #Drugs
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential Diagnosis ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Orotic aciduria, Drugs ... (e.g., hydroxyurea
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... . drugs, chemotherapy ... RBC defects (e.g ... #differential #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Foreign Surface (e.g
Torsades de Pointes
• "Twisting of the pointes" 
• QRS axis swings from positive to negative direction
precipitated by drugs ... TorsadesDePointes #Diagnosis ... #Cardiology #ECG ... #EKG